API monitoring detects Direct3D/OpenGL application start and apply special settings when defined by a profile. API monitoring also takes care of OSD features such as frames per second (FPS) counter, the CrossfireX bar and take graphics device screenshots which can not be possible using the standard Windows "Printscreen" hotkey.
On some circumstances the API monitoring code present on RadeonPro can prevent an application to start or work as expected, in such cases you can disable API monitoring for the profile item and still enjoy the normal profile settings application.
To disable API monitoring for a profile item, right-click the item and choose Disable API monitoring on context menu.